​CELL BIOLOGY OF INFLAMMATION
ENDOCORNEA. Corneal endothelial barrier disruption by osmotic and inflammatory stress.
Joint project between IIS-FJD and CSIC
Funded by the Instituto de Investigación Sanitaria from Fundación Jiménez Díaz, we have started a project to investigate the inflammatory response of corneal endothelial barriers, which are essential to maintain the homeostasis and deturgescence of the cornea. Our aim is to indentify targets to preserve corneal endothelial barrier function in response to different types of cellular stress.
Related Bibliography:
A human cellular system for analyzing signaling during corneal endothelial barrier dysfunction. Santander-García D., Ortega M.C., Benito-Martínez S., Barroso S., Jiménez-Alfaro I. and Millán J.
Experimental Eye Research. 2016, Sept 30. http://dx.doi.org/10.1016/j.exer.2016.09.010
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Activation of Rac1 and RhoA Preserve Corneal Endothelial Barrier Function. Ortega M.C., Santander-García D., Marcos-Ramiro B., Barroso S., Cox S., Jiménez-Alfaro I. and Millán J.
Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6210-6222. doi: 10.1167/iovs.16-20031.
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