​CELL BIOLOGY OF INFLAMMATION

The liver constitutes a paradigmatic model for investigating leukocyte infiltration into a tissue parenchyma, in which leukocytes egress from the sinusoids and interact with hepatic cells. Once leukocytes traverse the endothelial barrier, they establish adhesions with parenchymal cells, searching for the inflammatory focus and for dysfunctional cells. This is essential for immune-surveillance, the control of cancer development and infections, as well as for tissue regeneration. Aberrant leukocyte-hepatocyte interactions can exacerbate liver damage and even trigger liver failure in autoimmune diseases, in allograft rejection or upon severe trauma. We are currently investigating the effect of TNF on human hepatic cell barriers and the molecular mechanisms that regulate leukocyte-hepatic cell interactions.

 

 

Related Bibliography:

 

Reglero-Real N, García-Weber D, Millán J. Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue.

Mediators of Inflammation. 2016;2016:7650260. doi: 10.1155/2016/7650260. Epub 2016 Jan 28. Review.

 

Reglero-Real N, Álvarez-Varela A, Cernuda-Morollón E, Feito J, Marcos-Ramiro B,Fernández-Martín L, Gómez-Lechón MJ, Muntané J, Sandoval P, Majano PL, Correas I, Alonso MA and Millán J. Apicobasal polarity controls lymphocyte adhesion to hepatic epithelial cells.

Cell Reports; 2014, Sep 25;8(6):1879-93. DOI: http://dx.doi.org/10.1016/j.celrep.2014.08.007.

 

Reglero-Real, N., Marcos-Ramiro, B. and Millán J. Endothelial membrane reorganization during leukocyte extravasation. 

Cell Molecular Life Sciences. 2012.   10.1007/s00018-012-0987-4.